Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/53399
Title: Extracellular glutamate accumulates only in final, ischemic stage of progressive epidural mass lesion in cats
Authors: Graf, Rudolf
Toyota, Shingo
Dohmen, Christian
Valentino, Mario
Weinhard, K.
Heiss, Wolf-Dieter
Keywords: Glutamic acid
Ischemia
Neurology
Intracranial hypertension
Issue Date: 2001
Publisher: Raven Press Publishers
Citation: Graf, R., Toyota, S., Dohmen, C., Valentino, M., Weinhard, K., & Heiss, W. D. (2001). Extracellular glutamate accumulates only in final, ischemic stage of progressive epidural mass lesion in cats. Journal of Cerebral Blood Flow and Metabolism, 21, S175.
Abstract: Epidural mass lesions may cause ischemia due to progressive intracranial hypertension. In order to 1) investigate the impact of intracranial pressure (ICP) on accumulation of neuroactive substances, and 2) test the significance of neurochemical monitoring for early prediction of fatal outcome, we gradually raised ICP in cats by inflation of an epidural balloon: We assessed extracellular substrate alterations in the contralateral cortex in relation to changes of ICP, cerebral perfusion pressure (CPP) and mean arterial blood pressure (MABP). In a complementary experiment, regional cerebral blood flow was assessed by sequential positron emission tomography (PET).
URI: https://www.um.edu.mt/library/oar/handle/123456789/53399
Appears in Collections:Scholarly Works - FacM&SPB



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