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Title: Lateral habenula regulates temporal pattern organization of rat exploratory behavior and acute nicotine-induced anxiety in hole board
Authors: Casarrubea, Maurizio
Davies, Caitlin
Faulisi, Fabiana
Partdrige, Lucy
Chambers, Stephanie
Pierucci, Massimo
Colangeli, Roberto
Cassar, Daniel
Valentino, Mario
Muscat, Richard
Benigno, Arcangelo
Crescimanno, Giuseppe
Di Giovanni, Giuseppe
Keywords: Anxiety
Animal behavior
Nicotine -- Health aspects
Observation (Scientific method)
Issue Date: 2013-01-23
Publisher: Frontiers Research Foundation
Citation: Casarrubea, M., Davies, C., Faulisi, F., Partdrige, L., Chambers, S., Pierucci, M., ...Di Giovanni, G. (2013). Lateral habenula regulates temporal pattern organization of rat exploratory behavior and acute nicotine-induced anxiety in hole board. Frontiers in Cellular Neuroscience.
Abstract: Nicotine is one of the most addictive drugs of abuse. Tobacco smoking is a major cause of many health problems worldwide, and is the first preventable cause of death. Several findings show that nicotine exerts significant aversive as well as the well-known rewarding motivational effects. Less certain is the anatomical substrate that mediates or enables nicotine aversion. Here we have focused on nicotine-induced anxiety-like behavior in unlesioned and lesioned lateral habenula (LHb) rats. Firstly, we showed that acute nicotine induces anxiogenic effects in rats at the doses investigated (0.1, 0.5, and 1.0 mg/kg, i.p.) as measured by the hole-board apparatus, and manifested in behaviors such as decreased rearing and head-dipping and increased grooming. No changes in locomotor behavior were observed at any of the nicotine doses given. T-pattern analysis of the behavioral outcomes revealed a drastic reduction and disruption of complex behavioral patterns induced by all three nicotine doses, with the maximum effect for 1 mg/kg. Lesion of the LHb induced a significant anxiogenic effect, reduced the mean occurrences of T-patterns detected, and strikingly reverted the nicotine-induced anxiety to an anxiolytic effect. We suggest that LHb is critically involved in emotional behavior states and in nicotine-induced anxiety, most likely through modulating serotonergic/dopaminergic nuclei.
Appears in Collections:Scholarly Works - FacM&SPB

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