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https://www.um.edu.mt/library/oar/handle/123456789/53890
Title: | Two-photon imaging of cell-specific fluorophores in transgenic mice – an exploratory tool to study mechanisms of white matter injury |
Authors: | Valentino, Mario Goldberg, Mark P. |
Keywords: | Photons Imaging systems Cell differentiation -- Molecular aspects Fluoropolymers Transgenic mice -- Laboratory manuals White matter |
Issue Date: | 2006 |
Publisher: | University of Malta. Medical School |
Citation: | Valentino, M., & Goldberg, M. P. (2006). Two-photon imaging of cell-specific fluorophores in transgenic mice – an exploratory tool to study mechanisms of white matter injury. Malta Medical Journal, 18, 42 |
Abstract: | Relatively little is known about specific pathways leading to structural and functional disruption of axons and glial cells in white matter. Because focal cerebral ischemia in humans damages both gray and white matter, an understanding of white matter injury is important in devising potential therapeutic approaches. We have developed a novel brain slice model from transgenic mice under control of cell-specific promoters to understand interactions between oligodendrocytes and axons under high resolution twophoton microscopy. Our data extends over previous findings the vulnerability of oligodendrocytes and axons both in culture and in slice preparations to glutamate toxicity during stroke and hypoglycemia. Conditions as different as stroke, trauma, perinatal brain injury, and multiple sclerosis may share common mechanisms of white matter injury. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/53890 |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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Two_photon_imaging_of_cell_specific_fluorophores_in_transgenic_mice.pdf | 179.6 kB | Adobe PDF | View/Open |
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