Menopause and ageing of the skin and mucosae : impact on quality of life

Abstract

Cutaneous ageing manifests itself as a progressive reduction in maximum function and reserve capacity of its constitutive tissues. It is not a unique and uniform biological event. This organ is stratified into three layers-epidermis, dermis and subcutis. The atrophy of collagen is a major factor in skin ageing. Studies show a strong correlation between skin collagen loss and estrogen deficiency due to menopause. Estrogen use was associated with a statistically significant decrease in the likelihood of senile dry skin. Skin ageing, especially in the face, is associated with a progressive increase in extensibility and a reduction in skin elasticity. With increasing age, the skin becomes more fragile and susceptible to trauma, leading to more lacerations and bruising. Older women have been shown to heal less well. Large-scale clinical trials are necessary to help make informed recommendations regarding postmenopausal estrogen use and its role in prevention of skin ageing.