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Title: One pot aza-Friedel-Crafts multicomponent reaction under green chemistry conditions
Authors: Abdilla, Roderick (2017)
Keywords: Green chemistry
Friedel-Crafts reaction
Issue Date: 2017
Citation: Abdilla, R. (2017). One pot aza-Friedel-Crafts multicomponent reaction under green chemistry conditions (Master’s dissertation).
Abstract: Indole and its 3-substituted derivatives play crucial roles in various biological life forms and whilst some of them are naturally-occurring, others have been synthesized for their pharmaceutical capabilities. This study entailed synthesizing 3-substituted indoles via the one-pot multicomponent aza-Friedel-Crafts reactions, starting from a very wide range of aldehydes; primary, secondary and tertiary aromatic amines; and indoles. Following the principles of green chemistry, catalyst screening and condition optimization were performed on a model reaction. It was found that the reactions could be catalyzed by a heterogeneous, recyclable, easily and safely-prepared catalyst: silicotungstic acid supported on Amberlyst 15 beads.
Description: M.SC.CHEMISTRY
Appears in Collections:Dissertations - FacSci - 2017
Dissertations - FacSciChe - 2017

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