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dc.identifier.citationJohnson, A. (2017). Fluorescent molecular logic gates for pH and pE for cell imaging applications (Master’s dissertation).en_GB
dc.description.abstractNovel molecules for sensing pH and redox potential (pE) were designed and synthesised starting from the asymmetrical 1,8-naphltalimide fluorophore. Attachment of a proton receptor and/or electron donor at either the N-imide or 4-position resulted in the molecular engineering of several positional isomers. Three novel pH-pE molecules of various modular designs were synthesised including 'fluorophore-spacer1-receptor-spacer2-electron-donor', 'electron -donor-spacer1-fluorophore-spacer2-receptor', and 'electron-donor1-spacer1-receptor1-spacer2-fluorophore-spacer2-receptor2-spacer4-electron-donor2' prototype. The receptor was either N-methylethylenediamine or piperazine, whilst the electron-donor was forrocene, both of which were connected via methylene or ethylene spacers. In addition, two model fluoroscent pH indicators were designed and studied, based on a 'fluorsphore-spacer-receptor' format, whilst a third fluorescent pH indicator was synthesised with a 'receptor1-spacer1-fluorophore-spacer2-receptor2' modular format.en_GB
dc.titleFluorescent molecular logic gates for pH and pE for cell imaging applicationsen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.publisher.institutionUniversity of Maltaen_GB
dc.publisher.departmentFaculty of Science. Department of Chemistryen_GB
dc.contributor.creatorJohnson, Alex (2017)-
Appears in Collections:Dissertations - FacSci - 2017
Dissertations - FacSciChe - 2017

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