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https://www.um.edu.mt/library/oar/handle/123456789/86484| Title: | International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function |
| Authors: | Barnes, Nicholas M. Ahern, Gerard P. Becamel, Carine Bockaert, Joël Camilleri, Michael Chaumont-Dubel, Severine Claeysen, Sylvie Cunningham, Kathryn A. Fone, Kevin C. Gershon, Michael Di Giovanni, Giuseppe Goodfellow, Nathalie M. Halberstadt, Adam L. Hartley, Rachel M. Hassaine, Ghérici Herrick-Davis, Katharine Hovius, Ruud Lacivita, Enza Lambe, Evelyn K. Leopoldo, Marcello Olav Levy, Finn Lummis, Sarah C. R. Marin, Philippe Maroteaux, Luc McCreary, Andrew C. Nelson, David L. Neumaier, John F. Newman-Tancredi, Adrian Nury, Hugues Roberts, Alexander Roth, Bryan L. Roumier, Anne Sanger, Gareth J. Teitler, Milt Sharp, Trevor Villalón, Carlos M. Vogel, Horst Watts, Stephanie W. Hoyer, Daniel |
| Keywords: | Serotonin -- Receptors Serotonin -- Pharmacology Serotonin -- Agonists Serotonin -- Antagonists Serotonin -- Therapeutic use Serotonin uptake inhibitors |
| Issue Date: | 2021 |
| Publisher: | American Society for Pharmacology and Experimental Therapeutics |
| Citation: | Barnes, N. M., Ahern, G. P., Becamel, C., Bockaert, J., Camilleri, M., Chaumont-Dubel, S.,...Hoyer, D. (2021). International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function. Pharmacological reviews, 73(1), 310-520. |
| Abstract: | 5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and pathophysiological processes. The present review offers a framework for the official receptor nomenclature and a detailed understanding of each of the 14 5-HT receptor subtypes, their roles in the systems of the body, and, where appropriate, the (potential) utility of therapeutics targeting these receptors. Significance Statement—This review provides a comprehensive account of the classification and function of 5-hydroxytryptamine receptors, including how they are targeted for therapeutic benefit. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/86484 |
| Appears in Collections: | Scholarly Works - FacM&SPB |
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|---|---|---|---|---|
| International_Union_of_Basic_and_Clinical_Pharmacology_CX_Classification_of_receptors_for_5_hydroxytryptamine_pharmacology_and_function_2021.pdf Restricted Access | 12.3 MB | Adobe PDF | View/Open Request a copy |
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