Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/90328
Title: | Effects of substantia nigra pars compacta lesion on the behavioral sequencing in the 6-OHDA model of Parkinson’s disease |
Authors: | Casarrubea, Maurizio Di Giovanni, Giuseppe Crescimanno, Giuseppe Rosa, Ilaria Aiello, Stefania Di Censo, Davide Ranieri, Brigida Santangelo, Andrea Busatta, Daniele Cassioli, Emanuele Galante, Angelo Alecci, Marcello Florio, Tiziana M. |
Keywords: | Pars compacta Basal ganglia Dopamine -- Metabolism Oxidopamine Parkinson's disease -- Research |
Issue Date: | 2019-04 |
Publisher: | Elsevier |
Citation: | Casarrubea, M., Di Giovanni, G., Crescimanno, G., Rosa, I., Aiello, S., Di Censo, D., ... Florio, T. (2019). Effects of Substantia Nigra pars compacta lesion on the behavioral sequencing in the 6-OHDA model of Parkinson’s disease. Behavioural Brain Research, 362, 28-35. |
Abstract: | The basal ganglia circuitry plays a crucial role in the sequential organization of behavior. Here we studied the behavioral structure of the animals after 21 days of 6-OHDA-induced lesion of the dopaminergic nigrostriatal system. Frequencies and durations of individual components of the behavioral repertoire were calculated; moreover, whether a temporal organization of the activity was present, it was investigated by using T-pattern analysis, a multivariate approach able to detect the real-time sequential organization of behavior. Six sham-depleted and six rats with unilateral 6−OHDA-lesion of the Substantia Nigra pars compacta were used. As to quantitative evaluations, the comparison between lesioned and unlesioned rats revealed significant differences only for the mean occurrences of Walking, Immobile Sniffing and Stretched Sniffing, reduced in lesioned subjects. All the remaining components of the behavior did not show significant changes. On the other hand, results from T-pattern analysis showed a reduction of the number of different T-patterns, of their mean length and of their occurrences in 6-OHDA-lesioned rats. Overall, these results suggest that the main deficit in 6-OHDA-lesioned subjects, rather than in the production of individual behavioral components, lies in deficiencies of their sequential organization. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/90328 |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Effects of substantia nigra pars compacta lesion on the behavioral sequencing in the 6-OHDA.pdf Restricted Access | 2.24 MB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.