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Title: Noncoding RNAs in age-related cardiovascular diseases
Authors: Jusic, Amela
Thomas, Pınar Buket
Bezzina Wettinger, Stephanie
Doğan, Soner
Farrugia, Rosienne
Gaetano, Carlo
Güvenç Tuna, Bilge
Pinet, Florence
Robinson, Emma L.
Tual-Chalot, Simon
Stellos, Konstantinos
Devaux, Yvan
Keywords: Non-coding RNA
Cardiovascular system -- Diseases
Cardiovascular system -- Diseases -- Diagnosis
Cardiovascular system -- Diseases -- Treatment
Issue Date: 2022
Publisher: Elsevier
Citation: Jusic, A., Thomas, P. B., Wettinger, S. B., Doğan, S., Farrugia, R., Gaetano, C., ... & Devaux, Y. (2022). Noncoding RNAs in age-related cardiovascular diseases. Ageing Research Reviews, 77, 101610.
Abstract: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the adult population worldwide and represent a severe economic burden and public health concern. The majority of human genes do not code for proteins. However, noncoding transcripts play important roles in ageing that significantly increases the risk for CVDs. Noncoding RNAs (ncRNAs) are critical regulators of multiple biological processes related to ageing such as oxidative stress, mitochondrial dysfunction and chronic inflammation. NcRNAs are also involved in pathophysiological developments within the cardiovascular system including arrhythmias, cardiac hypertrophy, fibrosis, myocardial infarction and heart failure. In this review article, we cover the roles of ncRNAs in cardiovascular ageing and disease as well as their potential therapeutic applications in CVDs.
Appears in Collections:Scholarly Works - FacHScABS

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