Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/96308
Title: The role of host cell DNA methylation in the immune response to bacterial infection
Authors: Qin, Wanhai
Scicluna, Brendon P.
Poll, Tom van der
Keywords: DNA -- Analysis
Bacteria
Immune response
Infection
Mechanism of action (Biochemistry)
Information resources -- Reviews
Issue Date: 2021
Publisher: Frontiers Research Foundation
Citation: Qin, W., Scicluna, B. P., & van der Poll, T. (2021). The role of host cell DNA methylation in the immune response to bacterial infection. Frontiers in Immunology, 3073.
Abstract: Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic changes play a key role in the immune response to bacteria, among which DNA modifications that include methylation have received much attention in recent years. The extent of DNA methylation is well known to regulate gene expression. Whilst historically DNA methylation was considered to be a stable epigenetic modification, accumulating evidence indicates that DNA methylation patterns can be altered rapidly upon exposure of cells to changing environments and pathogens. Furthermore, the action of proteins regulating DNA methylation, particularly DNA methyltransferases and ten-eleven translocation methylcytosine dioxygenases, may be modulated, at least in part, by bacteria. This review discusses the principles of DNA methylation, and recent insights about the regulation of host DNA methylation during bacterial infection.
URI: https://www.um.edu.mt/library/oar/handle/123456789/96308
Appears in Collections:Scholarly Works - FacHScABS

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