Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/99069
Title: Key challenges for next‐generation pharmacogenomics
Authors: Kampourakis, Kostas
Vayena, Effy
Mitropoulou, Christina
Schaik, Ron H.
Cooper, David N.
Borg, Joseph J.
Patrinos, George P.
Keywords: Pharmacogenomics
Genomics -- Case studies
Molecular genetics
Nucleotides -- Synthesis
Issue Date: 2014
Publisher: EMBO
Citation: Kampourakis, K., Vayena, E., Mitropoulou, C., van Schaik, R. H., Cooper, D. N., Borg, J., & Patrinos, G. P. (2014). Key challenges for next‐generation pharmacogenomics: Science & Society series on Science and Drugs. EMBO Reports, 15(5), 472-476.
Abstract: The “post-genomic revolution” has advanced our understanding of the molecular etiology of a range of human genetic diseases, which might lead to improved disease prognosis and treatment. Over the past decade, genomics research has revealed the genomic variants underlying diseases, from single nucleotide variations to complex genome rearrangements, and/or altered gene expression patterns that lead directly to pathogenesis. These findings have enormous potential to guide physicians in their task of estimating disease risk and deciding on the most efficient and safe treatment options. More generally, genomic research could catalyze the maturation of individualized healthcare by considering each person’s genomic profile alongside his or her clinical condition to personalize therapeutic interventions.
URI: https://www.um.edu.mt/library/oar/handle/123456789/99069
Appears in Collections:Scholarly Works - FacHScABS

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