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https://www.um.edu.mt/library/oar/handle/123456789/22584| Title: | Predicting dopaminergic effects of L-DOPA in the treatment for Parkinson's disease |
| Authors: | Navailles, Sylvia Di Giovanni, Giuseppe De Deurwaerdère, Philippe |
| Keywords: | Parkinson's disease -- Treatment Levodopa |
| Issue Date: | 2014 |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| Citation: | Navailles, S., Di Giovanni, G., & De Deurwaerdère, P. (2014). Predicting dopaminergic effects of L-DOPA in the treatment for Parkinson's disease. CNS Neuroscience & Therapeutics, 20(7), 699-701. |
| Abstract: | Numerous advances have been made in the understanding of the mechanism of action of the antiparkinsonian medicine L-DOPA. This has allowed for the development of interesting predictive models regarding the positive and side effects of this medication. Recently, a mathematical model has been developed to investigate the impact of L-DOPA on dopamine (DA) release from serotonergic (5-HT) terminals in the striatum. The parameters used to elaborate this model were partially based on experimental data and may not be sufficient to illustrate the biochemical effects of L-DOPA inside 5-HT terminals. |
| URI: | https://www.um.edu.mt/library/oar//handle/123456789/22584 |
| Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Navailles et al 2014.pdf Restricted Access | 82.56 kB | Adobe PDF | View/Open Request a copy |
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