Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/93233
Title: A mutation in the LRP4 gene is associated with bone mineral density in Maltese postmenopausal women
Authors: Formosa, Melissa Marie
Borg, Joseph J.
Bezzina Wettinger, Stephanie
Farrugia, Rosienne
Xuereb-Anastasi, Angela
Keywords: Osteoporosis -- Genetic aspects
Bone density
Osteoporosis in women -- Malta
Issue Date: 2014-05
Publisher: Springer Nature Limited
Citation: Formosa, M. M., Borg, J., Bezzina-Wettinger, S., Farrugia, R., & Xuereb-Anastasi, A. (2014). A mutation in the LRP4 gene is associated with bone mineral density in Maltese postmenopausal women. European Journal of Human Genetics, 22(s1), 97.
Abstract: BACKGROUND: Osteoporosis is a hereditary multifactorial skeletal disease characterised by low bone mass and increased fracture susceptibility. The low-density lipoprotein receptor-related protein 4 (LRP4) controls the actions of sclerostin which is a known inhibitor of the Wingless (Wnt)/Beta (β) catenin pathway involved in bone formation.
OBJECTIVE: To evaluate the effect of two non-synonymous coding polymorphisms rs6485702 (A>G) and rs2306033 (C>T) in relation to Bone Mineral Density (BMD) and different low-trauma fractures in Maltese postmenopausal women.
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URI: https://www.um.edu.mt/library/oar/handle/123456789/93233
Appears in Collections:Scholarly Works - FacHScABS

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