Prof. Giovanna Bosica

Prof. Giovanna Bosica

Prof. Giovanna Bosica

 Ph.D.

Professor

Room 310
Chemistry & Pharmacology Building
University of Malta
Msida
  +356 2340 3074
Giovanna Bosica graduated cum laude from the University of Camerino, Italy, in 1993 with a Laurea degree, equivalent to M.Sc.(Hons), in Chemistry and obtained her Ph.D. degree in Chemical Sciences, in the field of organic synthesis, in 1997 from the same institution. In 1995 during her Ph.D. she spent a six months research period at the University of Nijmegen, the Netherlands, as an Erasmus Fellow.
In 1999 she was appointed Assistant Professor of Organic Chemistry at the University of Camerino.
In October 2008 she moved to the University of Malta where she was appointed Associate Professor of Organic Chemistry in the Department of Chemistry and subsequently obtained the promotion to full Professor in March 2014. She lectures for different courses in the field of organic chemistry/synthesis and natural products.
She is member of the Royal Chemical Society (MRSC) since 2011 and of the American Chemical Society (ACS) since 2015.
She performs referee activity for several scientific international journals including Green Chemistry, RSC Advances, ChemComm, Catalysis Science & Technology and Synlett. She has tutored a number of students doing research at undergraduate and postgraduate level.
In March 2016 she joined the European COST Association, participating at the COST Action CA15106, C-H Activation in Organic Synthesis (CHAOS), as a MC member from Malta [CA15106 MT].
  • Organic Synthesis
  • Green Chemistry
  • Heterogeneous Catalysis
  • One-pot and Multicomponent Reactions
  • Natural Products
  • Heterocyclic Compounds

PUERTA, A., GALÁN, A.R., ABDILLA, R., DEMANUELE, K., FERNANDES, M.X., BOSICA, G. and PADRÓN, J.M., 2019. Naphthol-derived Betti bases as potential SLC6A14 blockers. Journal of Molecular and Clinical Medicine, 2(2), pp. 35-40.

BOSICA, G., ABDILLA, R. and DEMANUELE, K., 2018. Revisiting the Betti Synthesis: Using a Cheap, Readily Available, Recyclable Clay Catalyst under Solventless Conditions. European Journal of Organic Chemistry, 2018(44), pp. 6127-6133.

BOSICA, G. and ZAMMIT, R., 2018. One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions. PeerJ, 6, pp. e5065.

BOSICA, G. and ABDILLA, R., 2017. The KA2 coupling reaction under green, solventless, heterogeneous catalysis. Journal of Molecular Catalysis A: Chemical, 426, Part B, pp. 542-549.

BOSICA, G. and ABDILLA, R., 2017. A regioselective one-pot aza-Friedel–Crafts reaction for primary, secondary and tertiary anilines using a heterogeneous catalyst. Green Chemistry, 19(23), pp. 5683-5690.

BOSICA, G. and POLIDANO, K., 2017. Solvent-free Henry and Michael reactions with nitroalkanes promoted by potassium carbonate as a versatile heterogeneous catalyst. Journal of Chemistry, 2017.

BOSICA, G. and ABDILLA, R., 2016. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions. Molecules, 21(6), pp. 815-825.

BOSICA, G. and GABARRETTA, J., 2015. Unprecedented one-pot multicomponent synthesis of propargylamines using Amberlyst A-21 supported CuI under solvent-free conditions. RSC Advances, 5(57), pp. 46074.

BOSICA, G. and DEBONO, A.J., 2014. Uncatalyzed, green aza-Michael addition of amines to dimethyl maleate. Tetrahedron, 70(37), pp. 6607.

BOSICA, G., SPITERI, J. and BORG, C., 2014. Aza-Michael reaction: Selective mono- versus bis-addition under environmentally-friendly conditions. Tetrahedron, 70(14), pp. 2449.

ANGELES LOPEZ-GARCIA, MAYA, I., FERNANDEZ-BOLANOS, J., BOSICA, G. and BALLINI, R., 2010. 1-Alkoxyamino-2-nitroalkanes as key building blocks for a chemo- and diastereoselective synthesis of a new type of polyfunctionalized N-Alkoxypiperidine. European Journal of Organic Chemistry, (28), pp. 5482.

BALLINI, R., BOSICA, G., GABRIELLI, S. and PALMIERI, A., 2009. beta-Nitroacrylates and silyl enol ethers as key starting materials for the synthesis of polyfunctionalized beta-nitro esters and 1,2-oxazine-2-oxides. Tetrahedron, 65(15), pp. 2916.

BALLINI, R., BOSICA, G., PALMIERI, A. and BAKHTIARI, K., 2009. Solvent-free, anti-Michael addition of active methylene derivatives to beta-nitroacrylates: Eco-friendly, chemoselective synthesis of polyfunctionalized nitroalkanes. Synlett, (2), pp. 268.

BALLINI, R., BAZAN, N.A., BOSICA, G. and PALMIERI, A., 2008. Uncatalyzed, anti-Michael addition of amines to beta-nitroacrylates: practical, eco-friendly synthesis of beta-nitro-alpha-amino esters. Tetrahedron letters, 49(24), pp. 3865.

BALLINI, R., BOSICA, G., PALMIERI, A., PIZZO, F. and VACCARO, L., 2008. Isolute? Si-carbonate catalyzes the nitronate addition to both aldehydes and electron-poor alkenes under solvent-free conditions. Green Chemistry, 10(5), pp. 541.

BALLINI, R., BARBONI, L., BOSICA, G., FIORINI, D. and PALMIERI, A., 2006. Synthesis of fine chemicals by the conjugate addition of nitroalkanes to electrophilic alkenes. Pure and applied chemistry, 78(10), pp. 1857-1866.

BALLINI, R., BOSICA, G., FIORINI, D. and PALMIERI, A., 2005. Acyclic alpha-nitro ketones: A versatile class of alpha-functionalized ketones in organic synthesis. Tetrahedron, 61(38), pp. 8971.

BALLINI, R., BOSICA, G., FIORINI, D. and PALMIERI, A., 2005. Neutral alumina catalysed synthesis of 3-nitro-1,2-dihydroquinolines and 3-nitrochromenes, under solvent-free conditions, via tandem process. Green Chemistry, 7(12), pp. 825.

BALLINI, R., BOSICA, G., FIORINI, D. and PALMIERI, A., 2005. The Nitroaldol (Henry) Reaction as the Key Step for the Synthesis of Some Natural Products. Frontiers in Natural Product Chemistry, 1(1), pp. 37-41.

BALLINI, R., BOSICA, G., FIORINI, D., PALMIERI, A. and PETRINI, M., 2005. Conjugate additions of nitroalkanes to electron-poor alkenes: Recent results. Chemical reviews, 105(3), pp. 933.

MAGGI, R., BOSICA, G., GHERARDI, S., ORO, C. and SARTORI, G., 2005. ZnNaY zeolite catalysed reaction of beta-dicarbonyl compounds with ethyl cyanoformate under solventless conditions. Green Chemistry, 7(4), pp. 182.

BALLINI, R., BARBONI, L., BOSICA, G., FIORINI, D., MIGNINI, E. and PALMIERI, A., 2004. Fast diastereoselective Baylis-Hillman reaction by nitroalkenes: Synthesis of di- and triene derivatives. Tetrahedron, 60(23), pp. 4995.

BALLINI, R., BOSICA, G., FIORINI, D., GIL, M.V. and PALMIERI, A., 2004. A new, one pot synthesis of alkylated methyl tri- and tetracarboxylate derivatives by nitrolkanes. Synthesis, (4), pp. 605.

BALLINI, R., BOSICA, G., FIORINI, D. and PALMIERI, A., 2004. One-pot synthesis of 1,3-dinitroalkanes under heterogeneous catalysis. Synthesis, (12), pp. 1938.

SARTORI, G., BALLINI, R., BIGI, F., BOSICA, G., MAGGI, R. and RIGHI, P., 2004. Protection (and Deprotection) of Functional Groups in Organic Synthesis by Heterogeneous Catalysis. Chemical reviews, 104(1), pp. 199.

BALLINI, R., BOSICA, G., CIOCI, G., FIORINI, D. and PETRINI, M., 2003. Conjugate addition of nitroalkanes to N-substituted maleimides. Synthesis of 3-alkylsuccinimides and pyrrolidines. Tetrahedron, 59(20), pp. 3603.

BALLINI, R., BOSICA, G. and FIORINI, D., 2003. Uncatalyzed conversion of linear alpha-nitro ketones into amides by reaction with primary amines under solventless conditions. Tetrahedron, 59(8), pp. 1143.

BALLINI, R., BOSICA, G., LIVI, D., PALMIERI, A., MAGGI, R. and SARTORI, G., 2003. Use of heterogeneous catalyst KG-60-NEt2 in Michael and Henry reactions involving nitroalkanes. Tetrahedron letters, 44(11), pp. 2271.

BALLINI, R., BOSICA, G., PALMIERI, A., PETRINI, M. and PIERANTOZZI, C., 2003. Conjugate addition of nitroalkanes to dimethyl maleate. Regioselective formation of both monoesters of 2-alkylsuccinic acids. Tetrahedron, 59(37), pp. 7283.

BADIOLI, M., BALLINI, R., BARTOLACCI, M., BOSICA, G., TORREGIANI, E. and MARCANTONI, E., 2002. Addition of organocerium reagents to morpholine amides: synthesis of important pheromone components of Achaea janata. The Journal of organic chemistry, 67(25), pp. 8938.

BALLINI, R., BARBONI, L., BOSICA, G. and FIORINI, D., 2002. One-pot synthesis of gamma-diketones, gamma-keto esters, and conjugated cyclopentenones from nitroalkanes. Synthesis, (18), pp. 2725.

BALLINI, R., BARBONI, L., BOSICA, G., FIORINI, D. and GIL, M.V., 2002. Michael addition of nitroalkanes to dimethyl citraconate, with DBU as base: An unexpected, one-pot synthesis of polyfunctionalized carbonyl derivatives. Synlett, (10), pp. 1706.

BALLINI, R., BOSICA, G., FIORINI, D., MAGGI, R., RIGHI, P., SARTORI, G. and SARTORIO, R., 2002. MCM-41-TBD as a new, efficient, supported heterogeneous catalyst for the synthesis of thioureas. Tetrahedron letters, 43(47), pp. 8445.

BALLINI, R., BOSICA, G., FIORINI, D. and PETRINI, M., 2002. Unprecedented, selective Nef reaction of secondary nitroalkanes promoted by DBU under basic homogeneous conditions. Tetrahedron letters, 43(30), pp. 5233.

BALLINI, R., BOSICA, G., FIORINI, D. and RIGHI, P., 2002. Nitroalkanes and dimethyl maleate as source of 3-alkyl succinic anhydrides and (E)-3-alkylidene succinic anhydrides. Synthesis, (5), pp. 681.

BALLINI, R., BOSICA, G., GIL, M.V., ROMÁN, E. and SERRANO, J.A., 2002. Preparation of enantiomerically pure 4-alkyl-5-formyl-4-nitrocyclohex-1-enes from 5-glyco-4-nitrocyclohex-1-enes. Tetrahedron: Asymmetry, 13(16), pp. 1773-1787.

BALLINI, R., BOSICA, G., FIORINI, D., GIL, M.V. and PETRINI, M., 2001. Stereoselective synthesis of (E)-4-alkylidenecyclopent-2-en-1-ones by a tandem ring closure-Michael addition-elimination. Organic letters, 3(9), pp. 1265.

BALLINI, R., BARBONI, L., BOSICA, G., FIORINI, D., VICTORIA GIL, M. and PETRINI, M., 2001. Synthesis of functionalized nitrocyclohexene derivatives from 2-nitrocycloalkanones, via anionic domino reactions. Tetrahedron, 57(28), pp. 6079.

BALLINI, R., BOSICA, G., CONFORTI, M.L., MAGGI, R., MAZZACANI, A., RIGHI, P. and SARTORI, G., 2001. Three-component process for the synthesis of 2-amino-2-chromenes in aqueous media. Tetrahedron, 57(7), pp. 1395.

BALLINI, R., BOSICA, G., COSSU, S., DE LUCCHI, O. and PELUSO, P., 2001. Observations on the alkylation of beta-acetalic carbanions: Monoalkylation versus dialkylation and elimination. Tetrahedron, 57(20), pp. 4461.

BALLINI, R., BOSICA, G. and FIORINI, D., 2001. Stereoselective preparation of (E)-epsilon-nitro-beta,gamma-unsaturated methyl esters: Amberlyst A 27, using microwave, as superior catalyst for the 1,6-conjugate addition of nitroalkanes to methyl 1,3-butadiene-1-carboxylate. Tetrahedron letters, 42(48), pp. 8471.

BALLINI, R., BOSICA, G., FIORINI, D. and GIARLO, G., 2001. Synthesis of 3-alkyl-2, 5-dimethylfuran derivatives by indirect alkylation of 2, 5-dimethylfuran with aliphatic nitrocompounds. Synthesis, 2001(13), pp. 2003-2006.

BALLINI, R., BOSICA, G. and LIVI, D., 2001. A new synthesis of exo-methylene butyrolactones from nitroalkanes. Synthesis, 2001(10), pp. 1519-1522.

BALLINI, R., BOSICA, G., MAGGI, R., MAZZACANI, A., RIGHI, P. and SARTORI, G., 2001. Amberlyst® 15 as a mild, chemoselective and reusable heterogeneous catalyst for the conversion of carbonyl compounds to 1, 3-oxathiolanes. Synthesis, 2001(12), pp. 1826-1829.

BALLINI, R., BOSICA, G., MAGGI, R., RICCIUTELLI, M., RIGHI, P., SARTORI, G. and SARTORIO, R., 2001. Clay-catalysed solventless synthesis of trans-chalcones. Green Chemistry, 3(4), pp. 178-180.

BALLINI, R., BARBONI, L. and BOSICA, G., 2000. Nitroalkanes as a New, Convenient Source of 1-Acyl-2,5-dialkylbenzene Derivatives, in Two Steps. Journal of Organic Chemistry, 65(19), pp. 6261.

BALLINI, R., BARBONI, L., BOSICA, G., FILIPPONE, P. and PERETTI, S., 2000. One-pot diastereoselective synthesis of 2-acyl-4-nitrocyclohexanol derivatives in aqueous medium. Tetrahedron, 56(24), pp. 4095.

BALLINI, R., BARBONI, L., BOSICA, G. and PETRINI, M., 2000. 2,5-Dialkylfurans and nitroalkanes as source of 2,3,5-trialkylpyrroles. Synlett, (3), pp. 391.

BALLINI, R., BOSICA, G., MARCANTONI, E., VITA, P. and BARTOLI, G., 2000. First TiCl4-mediated diastereoselective reduction of alpha-nitro ketones to anti-beta-nitro alcohols by BH3?SME2. Journal of Organic Chemistry, 65(18), pp. 5854.

BALLINI, R., BOSICA, G., MASE, A. and PETRINI, M., 2000. Synthesis of (E)-3-alkylidenepyrrolidines by nucleophilic ring closure of (E)-2-alkylidene-1,4-diol derivatives. European Journal of Organic Chemistry, (16), pp. 2927.

CURINI, M., EPIFANO, F., MARCOTULLIO, M.C., ROSATI, O., BALLINI, R. and BOSICA, G., 2000. Alumina promoted cyclization of alpha-nitro-oximes: A new entry to the synthesis of 1,2,5-oxadiazoles N-oxides (furoxans). Tetrahedron letters, 41(45), pp. 8817.

BALLINI, R., BOSICA, G., DAMIANI, M. and RIGHI, P., 1999. Nitroalkanes as a new source of 2-alkylidene-1,4-diols, in two steps. Tetrahedron, 55(47), pp. 13451.

BALLINI, R., BOSICA, G. and PARRINI, M., 1999. Fast nitroaldol reaction using powdered KOH in dry media. Chemistry Letters, (10), pp. 1105.

BALLINI, R., BOSICA, G., PETRELLI, L. and PETRINI, M., 1999. A New Two-Step Synthesis of 2-Alkylated 1, 4-Diketones and α-Alkylated γ-Keto Esters. Synthesis, 1999(07), pp. 1236-1240.

BALLINI, R., BORDONI, M., BOSICA, G., MAGGI, R. and SARTORI, G., 1998. Solvent free synthesis and deprotection of 1,1-diacetates over a commercially available zeolite Y as a reusable catalyst. Tetrahedron letters, 39(41), pp. 7587.

BALLINI, R. and BOSICA, G., 1998. Conjugated addition reactions of nitroalkanes with electrophilic alkenes in aqueous media. European Journal of Organic Chemistry, (2), pp. 355.

BALLINI, R. and BOSICA, G., 1998. Synthesis of (E)-4-oxonon-2-enoic acid, a natural antibiotic produced by streptomyces olivaceus. Journal of natural products, 61(5), pp. 673-674.

BALLINI, R., BOSICA, G., CARLONI, S., CIARALLI, L., MAGGI, R. and SARTORI, G., 1998. Zeolite HSZ-360 as a new reusable catalyst for the direct acetylation of alcohols and phenols under solventless conditions. Tetrahedron letters, 39(33), pp. 6049.

BALLINI, R., BOSICA, G., FRULLANTI, B., MAGGI, R., SARTORI, G. and SCHROER, F., 1998. 1,3-Dioxolanes from carbonyl compounds over zeolite HSZ-360 as a reusable, heterogeneous catalyst. Tetrahedron letters, 39(12), pp. 1615.

BALLINI, R., BOSICA, G. and GIGLI, F., 1998. alpha-nitrocycloalkanones as a new source for the one-pot synthesis of functionalized 1,4-diketones, gamma-oxoaldehydes, gamma-ketoesters, and methyl omega- oxoalkanoates. Tetrahedron, 54(26), pp. 7573.

BALLINI, R., BOSICA, G. and PARRINI, M., 1998. A one pot, solvent-free synthesis of acyclic alpha-nitro ketones through the nitroaldol reaction. Tetrahedron letters, 39(43), pp. 7963.

BALLINI, R. and BOSICA, G., 1997. alpha-nitrocycloalkanones as a source of alpha,omega,-dicarboxylic acid dimethyl esters. Tetrahedron, 53(47), pp. 16131.

BALLINI, R. and BOSICA, G., 1997. Formation of Carbon-Carbon Bond via Nitroalkanes under Heterogeneous Catalyst. . Recent Res. Devel. in Organic Chem.. Trivandrum, India: Transworld Research Network Ed., pp. vol.1 pag.11.

BALLINI, R. and BOSICA, G., 1997. Nitroaldol Reaction in Aqueous Media: An Important Improvement of the Henry Reaction. Journal of Organic Chemistry, 62(2), pp. 425.

BALLINI, R., BOSICA, G., MAGGI, R. and SARTORI, G., 1997. Envirocat EPZG? as a New Heterogeneous Catalyst for the Regeneration of Ketones from Their Tosylhydrazones. Synlett, 1997(7), pp. 795.

BALLINI, R., BOSICA, G. and MECOZZI, T., 1997. C-C bond fission via sulphones: A new ring cleavage of cyclic beta-keto phenylsulphones. Tetrahedron, 53(21), pp. 7341.

BALLINI, R. and BOSICA, G., 1996. The Michael reaction of nitroalkanes with conjugated enones in aqueous media. Tetrahedron letters, 37(44), pp. 8027.

BALLINI, R. and BOSICA, G., 1996. A new two steps synthesis of α-substituted γ-methyl γ-lactones from nitroalkanes. Synlett, , pp. 1115.

BALLINI, R. and BOSICA, G., 1996. Nitroalkanes as alkyl anion synthons - A new approach to the synthesis of 2-substituted N-ethyl succinimides and 2-substituted succinate diesters via nitroalkanes. Liebigs Annales, (12), pp. 2087.

BALLINI, R., BOSICA, G. and FORCONI, P., 1996. Nitroaldol (Henry) reaction catalyzed by amberlyst A-21 as a far superior heterogeneous catalyst. Tetrahedron, 52(5), pp. 1677.

BALLINI, R., BOSICA, G. and MARCANTONI, E., 1996. A new 1,4-elimination of benzenesulfinic acid from beta-keto phenylsulphones via their tosylhydrazones. Tetrahedron, 52(32), pp. 10705.

COSSU, S., DE LUCCHI, O., FABRIS, F., BALLINI, R. and BOSICA, G., 1996. A Michael route to acetals and thioacetals: Preparation of acetals (thioacetals) of 2-sulfonylacetaldehyde from alkynyl and other unsaturated aryl sulfones. Synthesis, (12), pp. 1481.

BALLINI, R. and BOSICA, G., 1995. A direct method for the synthesis of polyfunctionalized unsaturated carbonyl derivatives by Michael addition of nitroalkanes to enediones with the help of DBU. Tetrahedron, 51(14), pp. 4213.

BALLINI, R. and BOSICA, G., 1995. A New, Very Short Preparation of 3-Benzoylcyclohexanone, a Key Building Block in Ketoprofen Synthesis. Organic Preparations and Procedures International, 27(5), pp. 561.

BALLINI, R. and BOSICA, G., 1995. Protecting Groups: Reactivities and Opportunities. . In: G. CASIRAGHI, ed, Seminars in Organic Synthesis. Società Chimica Italiana, pp. 161.

BALLINI, R., BOSICA, G. and RAFAIANI, G., 1995. Functionalized Nitroalkanes in Organic Synthesis. The First Concise Preparation of 4-Hydroxyheptadecan-7-one and 14-Hydroxyoctadecan-8-one, Two New Hydroxy Ketones Isolated from Chiococca alba. Helvetica chimica acta, 78(4), pp. 879.

BALLINI, R. and BOSICA, G., 1994. Chemoselective conversion of conjugated nitroalkenes into ketones by sodium borohydride-hydrogen peroxide: a new synthesis of 4-oxoalkanoic acids, dihydrojasmone and (±)-exo-brevicomin. Synthesis, , pp. 723.

BALLINI, R. and BOSICA, G., 1994. A New Stereoselective Synthesis of (E)-alpha,beta-Unsarurated-gamma-dicarbonyl Compounds by the Henry Reaction. Journal of Organic Chemistry, 59(18), pp. 5466.

BALLINI, R. and BOSICA, G., 1994. Synthesis of 1-phenylheptane-1, 5-dione, a new natural product found in Phellinus tremulae. Journal of natural products, 57(10), pp. 1462-1463.

BALLINI, R., BOSICA, G. and SCHAAFSTRA, R., 1994. Nitro Ketones in Organic Synthesis: A New, Short Synthesis of Racemic trans-2-Methyl-1,7-dioxaspiroundecane, trans,trans- and trans,cis-2,8-Dimethyl-1,7-dioxaspiroundecane by Henry Reaction. Liebigs Annalen der Chemie, (12), pp. 1235.

BALLINI, R., BOSICA, G. and USELLI, A., 1994. A Simple, Efficient, Two-Step Synthesis of Symmetric 2,7-Dialkyl-1,6-Dioxaspirononanes. Journal of Heterocyclic Chemistry, 31(1), pp. 259.

BALLINI, R. and BOSICA, G., 1993. A Novel, Two-step, Mild and Simple Synthesis of beta-, gamma-, and delta-Oxo Esters from omega-Nitro Esters. Journal of Chemical Research, Miniprint, (11), pp. 2901.

BALLINI, R. and BOSICA, G., 1993. A Two-Step Synthesis of 2-Methylheptadecane, the Sex Pheromone of the Tiger Moth, Using the Henry Reaction. J. Chem. Res. (S), , pp. 371.

  • CHE3390 - Synthetic Organic Chemistry
Affiliations
- Member of the Royal Society of Chemistry (MRSC)
- Member of the American Chemical Society (ACS)

Reviewer for a broad range of international journals including Green Chemistry, RSC Advances,
New Journal of Chemistry, Synlett, ChemComm, and Catalysis Science & Technology.

ORCID

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