The Valletta Campus, also known as the Old University Building, is one of Malta’s most historically significant academic sites. Construction began in 1595 under the Knights of St. John as a Jesuit college intended to promote higher education in philosophy, theology, and the sciences. By the early 17th century, it had become a central intellectual institution within Valletta.

Architecturally, the building reflects Renaissance ideals, with later Baroque additions enhancing its façade and internal spaces. Following the expulsion of the Jesuits in 1768, the Knights retained the building for academic use, and in 1769 it became the seat of the newly established University of Malta. During the brief French occupation, it functioned as an École Centrale, before returning to university use under British administration.

In the 19th and early 20th centuries, the Valletta Campus adapted to changing educational needs, though increasing demand eventually required relocation to larger facilities. After the opening of the Msida campus in 1968, Valletta’s role shifted.

Today, the Valletta Campus hosts research centres, international institutions, conferences, and ceremonial events. It remains a symbol of Malta’s academic heritage and a living link between past and present scholarship.