Prof. David Saliba

Prof. David Saliba

Prof. David Saliba


Associate Professor

Room 417
Biomedical Sciences Building
University of Malta
After reading for a PhD from the University of Edinburgh Dr Saliba worked as a postdoctoral fellow in the field of Inflammation and Immunity at Imperial College London (5 years) and University of Oxford (4 years). Dr. David Saliba also holds an honorary position as Research Fellow at the Kennedy Institute of Rheumatology, University of Oxford. As a postdoctoral researcher Dr. Saliba published several high impact, peer reviewed papers in journals including Nature, Cell Reports, Blood, PNAS and eLife, receiving over 700 citations in the field of immunology. He participated in EU-funded projects through European Research Council Advanced Grant (ERC-AdG), Seventh Framework Program (FP7), Human Frontier Science Project (HFSP) and Medical Research Council (MRC) grants. In the field of virology related research, Dr Saliba has also collaborated with the Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery consortium. He has been recently awarded an Emanuele Cancer Research Fund to investigate the role of immune cells in Pituitary Neuroendocrine tumours. Dr Saliba, together with his collaborators at Imperial College, has also successfully applied and published a US patent application [13/978,504] on inhibitors that modulate key regulators of the immune system.

SALIBA, D.G., CÉSPEDES-DONOSO, P.,F., BALINT, S., COMPEER, E.B., VALVO, S., KOROBCHEVSKAYA, K., MAYYA, V., PENG, Y., DONG, T. and TOGNOLI, M., 2019. Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T-cells. BioRxiv, , pp. 600551.

BALINT, S., SALIBA, D.G., CESPEDES, P.F., COMPEER, E.B., VALVO, S. and DUSTIN, M.L., 2018. T-cell synaptic ectosomes relay signals through microcluster transfer. Journal of Extracellular Vesicles, 7, pp. 252-252.

BYRNE, A.J., WEISS, M., MATHIE, S.A., WALKER, S.A., EAMES, H.L., SALIBA, D., LLOYD, C.M. and UDALOVA, I.A., 2017. A critical role for IRF5 in regulating allergic airway inflammation. Mucosal immunology, 10(3), pp. 716.

PAPA, I., SALIBA, D., PONZONI, M., BUSTAMANTE, S., CANETE, P.F., GONZALEZ-FIGUEROA, P., MCNAMARA, H.A., VALVO, S., GRIMBALDESTON, M. and SWEET, R.A., 2017. T FH-derived dopamine accelerates productive synapses in germinal centres. Nature, 547(7663), pp. 318.

SENEVIRATNE, A.N., EDSFELDT, A., COLE, J.E., KASSITERIDI, C., SWART, M., PARK, I., GREEN, P., KHOYRATTY, T., SALIBA, D. and GODDARD, M.E., 2017. Interferon regulatory factor 5 controls necrotic core formation in atherosclerotic lesions by impairing efferocytosis. Circulation, 136(12), pp. 1140-1154.

ALZAID, F., LAGADEC, F., ALBUQUERQUE, M., BALLAIRE, R., ORLIAGUET, L., HAINAULT, I., BLUGEON, C., LEMOINE, S., LEHUEN, A. and SALIBA, D.G., 2016. IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans. JCI insight, 1(20),.

WEISS, M., BYRNE, A.J., BLAZEK, K., SALIBA, D.G., PEASE, J.E., PEROCHEAU, D., FELDMANN, M. and UDALOVA, I.A., 2015. IRF5 controls both acute and chronic inflammation. Proceedings of the National Academy of Sciences, 112(35), pp. 11001-11006.

SALIBA, D.G., HEGER, A., EAMES, H.L., OIKONOMOPOULOS, S., TEIXEIRA, A., BLAZEK, K., ANDROULIDAKI, A., WONG, D., GOH, F.G. and WEISS, M., 2014. IRF5: RelA interaction targets inflammatory genes in macrophages. Cell reports, 8(5), pp. 1308-1317.

UDALOVA, I.A., KRAUSGRUBER, T., FELDMANN, M., SALIBA, D. and EAMES, H., 2014. Treatment And Screening. US Patent App. 13/978,504.

RYZHAKOV, G., TEIXEIRA, A., SALIBA, D., BLAZEK, K., MUTA, T., RAGOUSSIS, J. and UDALOVA, I.A., 2013. Cross-species analysis reveals evolving and conserved features of the nuclear factor κB (NF-κB) proteins. Journal of Biological Chemistry, 288(16), pp. 11546-11554.

EAMES, H.L., SALIBA, D.G., KRAUSGRUBER, T., LANFRANCOTTI, A., RYZHAKOV, G. and UDALOVA, I.A., 2012. KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages. Immunobiology, 217(12), pp. 1315-1324.

LURON, L., SALIBA, D., BLAZEK, K., LANFRANCOTTI, A. and UDALOVA, I.A., 2012. FOXO 3 as a new IKK‐ε‐controlled check‐point of regulation of IFN‐β expression. European journal of immunology, 42(4), pp. 1030-1037.

CUHLMANN, S., VAN, D.H., SALIBA, D., TREMOLEDA, J.L., KHALIL, M., ZAKKAR, M., CHAUDHURY, H., LUONG, L.A., MASON, J.C. and UDALOVA, I., 2011. Disturbed blood flow induces RelA expression via c-Jun N-terminal kinase 1: a novel mode of NF-κB regulation that promotes arterial inflammation. Circulation research, 108(8), pp. 950-959.

KRAUSGRUBER, T., SALIBA, D., EAMES, H., WILLIAMS, L., SMALLIE, T., BLAZEK, K. and UDALOVA, I., 2011. Novel role of IRF5 in transcriptional inhibition of human IL-10 gene expression: PS2-062. Cytokine, 56(1),.

KRAUSGRUBER, T., SALIBA, D., EAMES, H., WILLIAMS, L., SMALLIE, T., BLAZEK, K. and UDALOVA, I.A., 2011. Novel role of IRF5 in transcriptional inhibition of human IL-10 gene expression.

WONG, D., TEIXEIRA, A., OKONOMOPOULOS, S., HUMBURG, P., LONE, I.N., SALIBA, D., SIGGERS, T., BULYK, M., ANGELOV, D. and DIMITRIOV, S., 2011. Deep-sequencing assisted characterization of NF-B DNA-binding specifities advances the interpretation of genetic functional traits. Genome biology, 12(7), pp. R70.

WONG, D., TEIXEIRA, A., OIKONOMOPOULOS, S., HUMBURG, P., LONE, I.N., SALIBA, D., SIGGERS, T., BULYK, M., ANGELOV, D. and DIMITROV, S., 2011. Extensive characterization of NF-κB binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits. Genome biology, 12(7), pp. R70.

EAMES, H.L., SALIBA, D., WAIT, R. and UDALOVA, I.A., 2010. IRF5 interactome: search for novel therapeutic targets.

KRAUSGRUBER, T., SALIBA, D., BLAZEK, K., LOCKSTONE, H., SAHGAL, N., ALZABIN, S., TEIXEIRA, A., HUSSELL, T., RAGOUSSIS, J. and UDALOVA, I., 2010. IRF5 as a defining factor of M1 macrophage polarization. Cytokine, 52(1),.

KRAUSGRUBER, T., THOMSON, S., SALIBA, D. and UDALOVA, I., 2008. 296 Role of interferon regulatory factor 5 in regulation of the human tumor necrosis factor gene expression. Cytokine, 43(3),.

SHIMIZU, H., SALIBA, D., WALLACE, M., FINLAN, L., LANGRIDGE-SMITH, P. and HUPP, T.R., 2006. Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo. Biochemical Journal, 397(2), pp. 355-367.

  • ABS5001 - Advanced Genetics and Molecular Techniques
  • ANA5604 - Cell Therapy
  • CPH2904 - Biological Drugs, Vaccines, Gene Therapy and Pharmacological Biotechnology
  • CPH2910 - Pharmacology Seminars 2
  • MDS1010 - Blood and Body Defence Mechanisms
  • MLS1001 - Introduction to Biomedical Biochemistry and Cell Biology
  • MLS2004 - Immunology
  • MLS3014 - Literature Review
  • MLS4003 - Applied Immunohaematology
  • PHB1102 - Renal Physiology and Haematology
  • PHB2502 - Molecular Haematology and Immunology
  • PHB3501 - Applied Molecular Bioscience 3: Bioanalysis