Artist, curator and academic, studied at the University of Leeds and the University of Central Lancashire in the UK. Produces gallery and site-specific artwork, objects and installations integrating traditional artistic practices with digital and electronic media.

Over the past thirty five years, Briffa's work has been exhibited in museums and galleries internationally including the Pierides Museum of Contemporary Art in Nicosia, Cyprus; the Palais des Nations, United Nations Building, Geneva, Switzerland; the Museum of Modern Art, Vaduz, Liechtenstein; the Casoria Contemporary Art Museum, Naples, and Villa Manin Centre of Contemporary Art, Udine, Italy; MAC - Museo de Arte Contemporáneo de Santa Fe, Argentina; Palais Liechtenstein, Feldkirch, Austria; The Museum of Fine Arts, Cluj, Romania and the Museum of Modern Art, Tel Aviv, Israel amongst many others. He has also had commissioned projects at the Cork 2005, Pafos 2017, Valletta 2018 and Leeuwarden-Friesland 2018, European Capitals of Culture.

He has also been chosen to represent Malta in many international exhibitions, including the Venice Biennale of 1999 and of 2019 and artist in residence at the Edinburgh College of Art, Scotland in 1996 and Leeuwarden Capital of Culture in 2018. He is a fellow of Civitella Ranieri Foundation with Residency in 2018. His work forms part of many local and international private and public collections.

Vince Briffa has been involved in the creative industries since the 1980s and was instrumental in launching computer graphics for television broadcast in Malta.