The University today has eleven Faculties: Built Environment, Arts, Dental Surgery, Economics, Management & Accountancy, Education, Engineering, Information & Communication Technology, Laws, Medicine & Surgery, Science and Theology.

A number of interdisciplinary Institutes and Centres have been set up in various fields. The Institutes include Agriculture, Anglo-Italian Studies, Baroque Studies, Confucius, Criminology, International Environment, Health Care, Islands & Small States, Linguistics, Maltese Studies, Public Administration & Management, Physical Education & Sport, Sustainable Development, Sustainable Energy, Mediterranean Institute and Edward de Bono Institute for the Design & Development of Thinking.

The Centres comprise: Centre for Communication Technology,  Centre for Family Studies,  Centre for Labour Studies, Centre for Literacy, Euro-Mediterranean Centre for Educational Research, Centre for Environmental Education & Research, Euro-Mediterranean Centre on Insular Coastal Dynamics, European Centre of Educational Resilience & Socio-Emotional Health, European Centre for Gerontology, the European Documentation & Research Centre and the International Ocean Institute - Malta Operational Centre.

The Institute of Conservation and Management of Cultural Heritage (ICMCH) is the teaching and research arm of Heritage Malta. The Institute promotes and co-ordinates the pursuit of interdisciplinary training at professional, technical and craftsman levels in all aspects of conservation-restoration and management of cultural heritage. ICMCH makes use of Heritage Malta's Conservation Division's extensive facilities to provide courses including those leading to degrees conferred by the University of Malta.

Associated with the University is the Mediterranean Academy of Diplomatic Studies which was established by special agreement with the Graduate Institute of International Studies in Geneva.

The campus is also home to the IMO International Maritime Law Institute (IMLI).

The public response to the University of the Third Age has been very encouraging with membership constantly on the increase and all activities being well attended.